Brain-specific serine protease 4 (PRSS22)
Homo sapiens — UniProt Q9GZN4
Data last refreshed: (UniProt release unknown)
Key facts
Brain-specific serine protease 4 (PRSS22) is a protein from Homo sapiens identified by UniProt accession Q9GZN4, 317 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.
- UniProt accession: Q9GZN4; gene symbol PRSS22.
- Organism: Homo sapiens.
- Length: 317 amino acids.
- Top disease associations (Open Targets): blood protein measurement, Familial prostate cancer and prostate carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Brain-specific serine protease 4 |
|---|---|
| UniProt accession | Q9GZN4 |
| Gene | PRSS22 |
| Organism | Homo sapiens |
| Length | 317 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (34)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.22
- Familial prostate cancer · score 0.11
- prostate carcinoma · score 0.11
- prostate cancer · score 0.11
- hepatocellular carcinoma · score 0.08
- breast cancer · score 0.08
- cancer · score 0.06
- neoplasm · score 0.04
- Crohn's disease · score 0.03
- sessile serrated polyp · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZN4-F1 | alphafold | PREDICTED | 85.36 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZN4.
Amino-acid sequence (317 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PRSS22?
The strongest Open Targets associations for PRSS22 are blood protein measurement, Familial prostate cancer, prostate carcinoma, prostate cancer and hepatocellular carcinoma.
How long is the PRSS22 protein?
The Homo sapiens PRSS22 protein (UniProt Q9GZN4) is 317 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZN4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZN4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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