Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 (SLC6A16)
Homo sapiens — UniProt Q9GZN6
Data last refreshed: (UniProt release unknown)
Key facts
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 (SLC6A16) is a protein from Homo sapiens identified by UniProt accession Q9GZN6, 736 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.
- UniProt accession: Q9GZN6; gene symbol SLC6A16.
- Organism: Homo sapiens.
- Length: 736 amino acids.
- Target class: Transporter.
- Top disease associations (Open Targets): systemic lupus erythematosus, blood protein measurement and multiple sclerosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 |
|---|---|
| UniProt accession | Q9GZN6 |
| Gene | SLC6A16 |
| Organism | Homo sapiens |
| Length | 736 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Transporter (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (10)
Diseases linked to this target (Open Targets).
- systemic lupus erythematosus · score 0.09
- blood protein measurement · score 0.04
- multiple sclerosis · score 0.03
- Down syndrome · score 0.02
- osteosarcoma · score 0.02
- psoriasis · score 0.01
- clear cell renal carcinoma · score 0.00
- rhabdomyosarcoma · score 0.00
- papillary thyroid carcinoma · score 0.00
- hepatocellular carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZN6-F1 | alphafold | PREDICTED | 80.00 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZN6.
Amino-acid sequence (736 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC6A16?
The strongest Open Targets associations for SLC6A16 are systemic lupus erythematosus, blood protein measurement, multiple sclerosis, Down syndrome and osteosarcoma.
How long is the SLC6A16 protein?
The Homo sapiens SLC6A16 protein (UniProt Q9GZN6) is 736 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZN6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZN6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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