COMM domain-containing protein 5 (COMMD5)
Homo sapiens — UniProt Q9GZQ3
Data last refreshed: (UniProt release unknown)
Key facts
COMM domain-containing protein 5 (COMMD5) is a protein from Homo sapiens identified by UniProt accession Q9GZQ3, 224 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.
- UniProt accession: Q9GZQ3; gene symbol COMMD5.
- Organism: Homo sapiens.
- Length: 224 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, renal cell carcinoma and neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | COMM domain-containing protein 5 |
|---|---|
| UniProt accession | Q9GZQ3 |
| Gene | COMMD5 |
| Organism | Homo sapiens |
| Length | 224 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (22)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- renal cell carcinoma · score 0.07
- neoplasm · score 0.06
- cancer · score 0.05
- nonpapillary renal cell carcinoma · score 0.03
- Systemic lupus erythematosus · score 0.01
- hepatocellular carcinoma · score 0.01
- atherosclerosis · score 0.01
- kidney injury · score 0.01
- autoimmune disease · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZQ3-F1 | alphafold | PREDICTED | 83.99 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZQ3.
Amino-acid sequence (224 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with COMMD5?
The strongest Open Targets associations for COMMD5 are neurodegenerative disease, renal cell carcinoma, neoplasm, cancer and nonpapillary renal cell carcinoma.
How long is the COMMD5 protein?
The Homo sapiens COMMD5 protein (UniProt Q9GZQ3) is 224 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZQ3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZQ3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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