Neuropeptide FF receptor 1 (NPFFR1)
Homo sapiens — UniProt Q9GZQ6
Data last refreshed: (UniProt release unknown)
Key facts
Neuropeptide FF receptor 1 (NPFFR1) is a protein from Homo sapiens identified by UniProt accession Q9GZQ6, 430 residues long. MolForge cross-references it against 0 known binders and 66 disease associations.
- UniProt accession: Q9GZQ6; gene symbol NPFFR1.
- Organism: Homo sapiens.
- Length: 430 amino acids.
- Top disease associations (Open Targets): IGF-1 measurement, neurodegenerative disease and primary ovarian insufficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Neuropeptide FF receptor 1 |
|---|---|
| UniProt accession | Q9GZQ6 |
| Gene | NPFFR1 |
| Organism | Homo sapiens |
| Length | 430 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (66)
Diseases linked to this target (Open Targets).
- IGF-1 measurement · score 0.28
- neurodegenerative disease · score 0.26
- primary ovarian insufficiency · score 0.07
- 46,XX gonadal dysgenesis · score 0.07
- inorganic pyrophosphatase measurement · score 0.06
- aspartate aminotransferase measurement · score 0.05
- hypergonadotropic hypogonadism-cataract syndrome · score 0.05
- spermatogenic failure 14 · score 0.05
- spermatogenic failure 13 · score 0.05
- erythrocyte count · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZQ6-F1 | alphafold | PREDICTED | 77.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZQ6.
Amino-acid sequence (430 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NPFFR1?
The strongest Open Targets associations for NPFFR1 are IGF-1 measurement, neurodegenerative disease, primary ovarian insufficiency, 46,XX gonadal dysgenesis and inorganic pyrophosphatase measurement.
How long is the NPFFR1 protein?
The Homo sapiens NPFFR1 protein (UniProt Q9GZQ6) is 430 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZQ6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZQ6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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