Microtubule-associated protein 1 light chain 3 beta (MAP1LC3B)
Homo sapiens — UniProt Q9GZQ8
Data last refreshed: (UniProt release unknown)
Key facts
Microtubule-associated protein 1 light chain 3 beta (MAP1LC3B) is a protein from Homo sapiens identified by UniProt accession Q9GZQ8, 125 residues long. MolForge cross-references it against 1 known binders and 401 disease associations.
- UniProt accession: Q9GZQ8; gene symbol MAP1LC3B.
- Organism: Homo sapiens.
- Length: 125 amino acids.
- Top disease associations (Open Targets): COVID-19, severe acute respiratory syndrome and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Microtubule-associated protein 1 light chain 3 beta |
|---|---|
| UniProt accession | Q9GZQ8 |
| Gene | MAP1LC3B |
| Organism | Homo sapiens |
| Length | 125 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (401)
Diseases linked to this target (Open Targets).
- COVID-19 · score 0.51
- severe acute respiratory syndrome · score 0.50
- neurodegenerative disease · score 0.37
- self reported educational attainment · score 0.29
- Abnormality of refraction · score 0.25
- neuroticism measurement · score 0.21
- mood instability measurement · score 0.21
- smoking status measurement · score 0.20
- smoking behaviour measurement · score 0.16
- breast carcinoma · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZQ8-F1 | alphafold | PREDICTED | 91.45 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZQ8.
Amino-acid sequence (125 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MAP1LC3B?
The strongest Open Targets associations for MAP1LC3B are COVID-19, severe acute respiratory syndrome, neurodegenerative disease, self reported educational attainment and Abnormality of refraction.
How long is the MAP1LC3B protein?
The Homo sapiens MAP1LC3B protein (UniProt Q9GZQ8) is 125 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZQ8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZQ8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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