Sentrin-specific protease 6 (SENP6)
Homo sapiens — UniProt Q9GZR1
Data last refreshed: (UniProt release unknown)
Key facts
Sentrin-specific protease 6 (SENP6) is a protein from Homo sapiens identified by UniProt accession Q9GZR1, 1112 residues long. MolForge cross-references it against 0 known binders and 86 disease associations.
- UniProt accession: Q9GZR1; gene symbol SENP6.
- Organism: Homo sapiens.
- Length: 1112 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, body height and appendicular lean mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sentrin-specific protease 6 |
|---|---|
| UniProt accession | Q9GZR1 |
| Gene | SENP6 |
| Organism | Homo sapiens |
| Length | 1112 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (86)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.51
- body height · score 0.36
- appendicular lean mass · score 0.34
- osteoarthritis, hip · score 0.31
- BMI-adjusted waist circumference · score 0.29
- sitting height measurement · score 0.26
- forced expiratory volume · score 0.25
- BMI-adjusted hip circumference · score 0.25
- age at menarche · score 0.23
- type 2 diabetes mellitus · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZR1-F1 | alphafold | PREDICTED | 54.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZR1.
Amino-acid sequence (1112 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SENP6?
The strongest Open Targets associations for SENP6 are neurodegenerative disease, body height, appendicular lean mass, osteoarthritis, hip and BMI-adjusted waist circumference.
How long is the SENP6 protein?
The Homo sapiens SENP6 protein (UniProt Q9GZR1) is 1112 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZR1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZR1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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