Very long chain fatty acid elongase 4 (ELOVL4)
Homo sapiens — UniProt Q9GZR5
Data last refreshed: (UniProt release unknown)
Key facts
Very long chain fatty acid elongase 4 (ELOVL4) is a protein from Homo sapiens identified by UniProt accession Q9GZR5, 314 residues long. MolForge cross-references it against 0 known binders and 243 disease associations.
- UniProt accession: Q9GZR5; gene symbol ELOVL4.
- Organism: Homo sapiens.
- Length: 314 amino acids.
- Top disease associations (Open Targets): Congenital ichthyosis - intellectual disability - spastic quadriplegia, spinocerebellar ataxia type 34 and Stargardt disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Very long chain fatty acid elongase 4 |
|---|---|
| UniProt accession | Q9GZR5 |
| Gene | ELOVL4 |
| Organism | Homo sapiens |
| Length | 314 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (243)
Diseases linked to this target (Open Targets).
- Congenital ichthyosis - intellectual disability - spastic quadriplegia · score 0.75
- spinocerebellar ataxia type 34 · score 0.72
- Stargardt disease · score 0.71
- congenital ichthyosis-intellectual disability-spastic quadriplegia syndrome · score 0.66
- BMI-adjusted waist circumference · score 0.39
- Retinal dystrophy · score 0.37
- waist-hip ratio · score 0.33
- spastic ataxia · score 0.27
- genetic disorder · score 0.18
- body mass index · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZR5-F1 | alphafold | PREDICTED | 83.47 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZR5.
Amino-acid sequence (314 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ELOVL4?
The strongest Open Targets associations for ELOVL4 are Congenital ichthyosis - intellectual disability - spastic quadriplegia, spinocerebellar ataxia type 34, Stargardt disease, congenital ichthyosis-intellectual disability-spastic quadriplegia syndrome and BMI-adjusted waist circumference.
How long is the ELOVL4 protein?
The Homo sapiens ELOVL4 protein (UniProt Q9GZR5) is 314 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZR5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZR5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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