Dynein axonemal intermediate chain 2 (DNAI2)
Homo sapiens — UniProt Q9GZS0
Data last refreshed: (UniProt release unknown)
Key facts
Dynein axonemal intermediate chain 2 (DNAI2) is a protein from Homo sapiens identified by UniProt accession Q9GZS0, 605 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.
- UniProt accession: Q9GZS0; gene symbol DNAI2.
- Organism: Homo sapiens.
- Length: 605 amino acids.
- Top disease associations (Open Targets): primary ciliary dyskinesia, bronchiectasis and Bronchiectasis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dynein axonemal intermediate chain 2 |
|---|---|
| UniProt accession | Q9GZS0 |
| Gene | DNAI2 |
| Organism | Homo sapiens |
| Length | 605 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (38)
Diseases linked to this target (Open Targets).
- primary ciliary dyskinesia · score 0.75
- bronchiectasis · score 0.37
- Bronchiectasis · score 0.37
- Parkinson disease · score 0.25
- multiple sclerosis · score 0.25
- lysosomal storage disease · score 0.25
- neurodegenerative disease · score 0.25
- Alzheimer disease · score 0.25
- PHF-tau measurement · score 0.09
- DNA methylation · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZS0-F1 | alphafold | PREDICTED | 84.16 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZS0.
Amino-acid sequence (605 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DNAI2?
The strongest Open Targets associations for DNAI2 are primary ciliary dyskinesia, bronchiectasis, Bronchiectasis, Parkinson disease and multiple sclerosis.
How long is the DNAI2 protein?
The Homo sapiens DNAI2 protein (UniProt Q9GZS0) is 605 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZS0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZS0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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