DNA-directed RNA polymerase I subunit RPA49 (POLR1E)
Homo sapiens — UniProt Q9GZS1
Data last refreshed: (UniProt release unknown)
Key facts
DNA-directed RNA polymerase I subunit RPA49 (POLR1E) is a protein from Homo sapiens identified by UniProt accession Q9GZS1, 419 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.
- UniProt accession: Q9GZS1; gene symbol POLR1E.
- Organism: Homo sapiens.
- Length: 419 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, endometrial cancer and metabolite measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DNA-directed RNA polymerase I subunit RPA49 |
|---|---|
| UniProt accession | Q9GZS1 |
| Gene | POLR1E |
| Organism | Homo sapiens |
| Length | 419 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (18)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- endometrial cancer · score 0.24
- metabolite measurement · score 0.14
- genetic disorder · score 0.12
- wellbeing measurement · score 0.03
- daytime rest measurement · score 0.03
- neuroticism measurement · score 0.02
- depressive symptom measurement · score 0.02
- diastolic blood pressure · score 0.02
- bipolar disorder · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZS1-F1 | alphafold | PREDICTED | 82.71 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZS1.
Amino-acid sequence (419 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with POLR1E?
The strongest Open Targets associations for POLR1E are neurodegenerative disease, endometrial cancer, metabolite measurement, genetic disorder and wellbeing measurement.
How long is the POLR1E protein?
The Homo sapiens POLR1E protein (UniProt Q9GZS1) is 419 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZS1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZS1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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