SRA stem-loop-interacting RNA-binding protein, mitochondrial (SLIRP)
Homo sapiens — UniProt Q9GZT3
Data last refreshed: (UniProt release unknown)
Key facts
SRA stem-loop-interacting RNA-binding protein, mitochondrial (SLIRP) is a protein from Homo sapiens identified by UniProt accession Q9GZT3, 109 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.
- UniProt accession: Q9GZT3; gene symbol SLIRP.
- Organism: Homo sapiens.
- Length: 109 amino acids.
- Top disease associations (Open Targets): mitochondrial encephalomyopathy, neurodegenerative disease and azoospermia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SRA stem-loop-interacting RNA-binding protein, mitochondrial |
|---|---|
| UniProt accession | Q9GZT3 |
| Gene | SLIRP |
| Organism | Homo sapiens |
| Length | 109 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (71)
Diseases linked to this target (Open Targets).
- mitochondrial encephalomyopathy · score 0.33
- neurodegenerative disease · score 0.20
- azoospermia · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- spermatogenic failure 65 · score 0.06
- spermatogenic failure 72 · score 0.06
- spermatogenic failure 56 · score 0.06
- spermatogenic failure 18 · score 0.06
- spermatogenic failure 46 · score 0.06
- spermatogenic failure 27 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZT3-F1 | alphafold | PREDICTED | 80.61 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZT3.
Amino-acid sequence (109 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLIRP?
The strongest Open Targets associations for SLIRP are mitochondrial encephalomyopathy, neurodegenerative disease, azoospermia, male infertility with teratozoospermia due to single gene mutation and spermatogenic failure 65.
How long is the SLIRP protein?
The Homo sapiens SLIRP protein (UniProt Q9GZT3) is 109 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZT3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZT3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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