Mucolipin-1 (MCOLN1)
Homo sapiens — UniProt Q9GZU1
Data last refreshed: (UniProt release unknown)
Key facts
Mucolipin-1 (MCOLN1) is a protein from Homo sapiens identified by UniProt accession Q9GZU1, 580 residues long. MolForge cross-references it against 0 known binders and 154 disease associations.
- UniProt accession: Q9GZU1; gene symbol MCOLN1.
- Organism: Homo sapiens.
- Length: 580 amino acids.
- Top disease associations (Open Targets): mucolipidosis type IV, genetic disorder and Lisch epithelial corneal dystrophy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mucolipin-1 |
|---|---|
| UniProt accession | Q9GZU1 |
| Gene | MCOLN1 |
| Organism | Homo sapiens |
| Length | 580 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (154)
Diseases linked to this target (Open Targets).
- mucolipidosis type IV · score 0.84
- genetic disorder · score 0.51
- Lisch epithelial corneal dystrophy · score 0.42
- neurodegenerative disease · score 0.39
- mucolipidosis · score 0.34
- Intellectual disability · score 0.32
- Corneal opacity · score 0.32
- periventricular leukomalacia · score 0.32
- Delayed speech and language development · score 0.32
- Growth delay · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZU1-F1 | alphafold | PREDICTED | 81.28 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZU1.
Amino-acid sequence (580 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MCOLN1?
The strongest Open Targets associations for MCOLN1 are mucolipidosis type IV, genetic disorder, Lisch epithelial corneal dystrophy, neurodegenerative disease and mucolipidosis.
How long is the MCOLN1 protein?
The Homo sapiens MCOLN1 protein (UniProt Q9GZU1) is 580 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZU1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZU1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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