Paternally-expressed gene 3 protein (PEG3)

Homo sapiens — UniProt Q9GZU2

Gene: PEG3Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Paternally-expressed gene 3 protein (PEG3) is a protein from Homo sapiens identified by UniProt accession Q9GZU2, 1588 residues long. MolForge cross-references it against 0 known binders and 117 disease associations.

UniProt accession: Q9GZU2; gene symbol PEG3.
Organism: Homo sapiens.
Length: 1588 amino acids.
Top disease associations (Open Targets): neurodegenerative disease, high density lipoprotein cholesterol measurement and triglyceride measurement.
3D structure: AlphaFold model available.

Target properties

Protein name	Paternally-expressed gene 3 protein
UniProt accession	Q9GZU2
Gene	PEG3
Organism	Homo sapiens
Length	1588 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (117)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.35
high density lipoprotein cholesterol measurement · score 0.26
triglyceride measurement · score 0.26
pancreatic adenocarcinoma · score 0.25
IGF-1 measurement · score 0.16
genetic disorder · score 0.12
appendicular lean mass · score 0.09
hepatocellular carcinoma · score 0.07
Down syndrome · score 0.05
neoplasm · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9GZU2-F1	alphafold	PREDICTED	44.54	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZU2.

Amino-acid sequence (1588 residues)

MLPPKHLSAT KPKKSWAPNL YELDSDLTKE PDVIIGEGPT DSEFFHQRFR NLIYVEFVGP RKTLIKLRNL CLDWLQPETR TKEEIIELLV LEQYLTIIPE KLKPWVRAKK PENCEKLVTL LENYKEMYQP EDDNNSDVTS DDDMTRNRRE SSPPHSVHSF SDRDWDRRGR SRDMEPRDRW SHTRNPRSRM PPRDLSLPVV AKTSFEMDRE DDRDSRAYES RSQDAESYQN VVDLAEDRKP HNTIQDNMEN YRKLLSLVQL AEDDGHSHMT QGHSSRSKRS AYPSTSRGLK TMPEAKKSTH RRGICEDESS HGVIMEKFIK DVSRSSKSGR ARESSDRSQR FPRMSDDNWK DISLNKRESV IQQRVYEGNA FRGGFRFNST LVSRKRVLER KRRYHFDTDG KGSIHDQKGC PRKKPFECGS EMRKAMSVSS LSSLSSPSFT ESQPIDFGAM PYVCDECGRS FSVISEFVEH QIMHTRENLY EYGESFIHSV AVSEVQKSQV GGKRFECKDC GETFNKSAAL AEHRKIHARG YLVECKNQEC EEAFMPSPTF SELQKIYGKD KFYECRVCKE TFLHSSALIE HQKIHFGDDK DNEREHERER ERERGETFRP SPALNEFQKM YGKEKMYECK VCGETFLHSS SLKEHQKIHT RGNPFENKGK VCEETFIPGQ SLKRRQKTYN KEKLCDFTDG RDAFMQSSEL SEHQKIHSRK NLFEGRGYEK SVIHSGPFTE SQKSHTITRP LESDEDEKAF TISSNPYENQ KIPTKENVYE AKSYERSVIH SLASVEAQKS HSVAGPSKPK VMAESTIQSF DAINHQRVRA GGNTSEGREY SRSVIHSLVA SKPPRSHNGN ELVESNEKGE SSIYISDLND KRQKIPAREN PCEGGSKNRN YEDSVIQSVF RAKPQKSVPG EGSGEFKKDG EFSVPSSNVR EYQKARAKKK YIEHRSNETS VIHSLPFGEQ TFRPRGMLYE CQECGECFAH SSDLTEHQKI HDREKPSGSR NYEWSVIRSL APTDPQTSYA QEQYAKEQAR NKCKDFRQFF ATSEDLNTNQ KIYDQEKSHG EESQGENTDG EETHSEETHG QETIEDPVIQ GSDMEDPQKD DPDDKIYECE DCGLGFVDLT DLTDHQKVHS RKCLVDSREY THSVIHTHSI SEYQRDYTGE QLYECPKCGE SFIHSSFLFE HQRIHEQDQL YSMKGCDDGF IALLPMKPRR NRAAERNPAL AGSAIRCLLC GQGFIHSSAL NEHMRLHRED DLLEQSQMAE EAIIPGLALT EFQRSQTEER LFECAVCGES FVNPAELADH VTVHKNEPYE YGSSYTHTSF LTEPLKGAIP FYECKDCGKS FIHSTVLTKH KELHLEEEEE DEAAAAAAAA AQEVEANVHV PQVVLRIQGL NVEAAEPEVE AAEPEVEAAE PEVEAAEPNG EAEGPDGEAA EPIGEAGQPN GEAEQPNGDA DEPDGAGIED PEERAEEPEG KAEEPEGDAD EPDGVGIEDP EEGEDQEIQV EEPYYDCHEC TETFTSSTAF SEHLKTHASM IIFEPANAFG ECSGYIERAS TSTGGANQAD EKYFKCDVCG QLFNDRLSLA RHQNTHTG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with PEG3?

The strongest Open Targets associations for PEG3 are neurodegenerative disease, high density lipoprotein cholesterol measurement, triglyceride measurement, pancreatic adenocarcinoma and IGF-1 measurement.

How long is the PEG3 protein?

The Homo sapiens PEG3 protein (UniProt Q9GZU2) is 1588 amino acids long.

Browse: Targets: P · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q9GZU2 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q9GZU2 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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