Transmembrane protein 39B (TMEM39B)
Homo sapiens — UniProt Q9GZU3
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 39B (TMEM39B) is a protein from Homo sapiens identified by UniProt accession Q9GZU3, 492 residues long. MolForge cross-references it against 0 known binders and 8 disease associations.
- UniProt accession: Q9GZU3; gene symbol TMEM39B.
- Organism: Homo sapiens.
- Length: 492 amino acids.
- Top disease associations (Open Targets): hepatocellular carcinoma, neoplasm and cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 39B |
|---|---|
| UniProt accession | Q9GZU3 |
| Gene | TMEM39B |
| Organism | Homo sapiens |
| Length | 492 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (8)
Diseases linked to this target (Open Targets).
- hepatocellular carcinoma · score 0.07
- neoplasm · score 0.02
- cancer · score 0.01
- autoimmune polyendocrine syndrome type 1 · score 0.01
- ulcerative colitis · score 0.01
- Obesity · score 0.00
- inflammatory bowel disease · score 0.00
- myeloid sarcoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZU3-F1 | alphafold | PREDICTED | 73.44 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZU3.
Amino-acid sequence (492 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM39B?
The strongest Open Targets associations for TMEM39B are hepatocellular carcinoma, neoplasm, cancer, autoimmune polyendocrine syndrome type 1 and ulcerative colitis.
How long is the TMEM39B protein?
The Homo sapiens TMEM39B protein (UniProt Q9GZU3) is 492 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZU3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZU3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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