Nyctalopin (NYX)
Homo sapiens — UniProt Q9GZU5
Data last refreshed: (UniProt release unknown)
Key facts
Nyctalopin (NYX) is a protein from Homo sapiens identified by UniProt accession Q9GZU5, 476 residues long. MolForge cross-references it against 0 known binders and 68 disease associations.
- UniProt accession: Q9GZU5; gene symbol NYX.
- Organism: Homo sapiens.
- Length: 476 amino acids.
- Top disease associations (Open Targets): congenital stationary night blindness, Retinal dystrophy and X-linked congenital stationary night blindness.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nyctalopin |
|---|---|
| UniProt accession | Q9GZU5 |
| Gene | NYX |
| Organism | Homo sapiens |
| Length | 476 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (68)
Diseases linked to this target (Open Targets).
- congenital stationary night blindness · score 0.67
- Retinal dystrophy · score 0.48
- X-linked congenital stationary night blindness · score 0.41
- Abnormality of the eye · score 0.26
- genetic disorder · score 0.19
- retinitis pigmentosa · score 0.12
- Autosomal dominant optic atrophy, classic type · score 0.06
- myopia · score 0.05
- Myopia · score 0.05
- Stargardt disease · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZU5-F1 | alphafold | PREDICTED | 81.88 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZU5.
Amino-acid sequence (476 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NYX?
The strongest Open Targets associations for NYX are congenital stationary night blindness, Retinal dystrophy, X-linked congenital stationary night blindness, Abnormality of the eye and genetic disorder.
How long is the NYX protein?
The Homo sapiens NYX protein (UniProt Q9GZU5) is 476 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZU5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZU5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.