High affinity choline transporter 1 (SLC5A7)
Homo sapiens — UniProt Q9GZV3
Data last refreshed: (UniProt release unknown)
Key facts
High affinity choline transporter 1 (SLC5A7) is a protein from Homo sapiens identified by UniProt accession Q9GZV3, 580 residues long. MolForge cross-references it against 1 known binders and 213 disease associations.
- UniProt accession: Q9GZV3; gene symbol SLC5A7.
- Organism: Homo sapiens.
- Length: 580 amino acids.
- Target class: Transporter.
- Top disease associations (Open Targets): Presynaptic congenital myasthenic syndromes, Congenital myasthenic syndromes and distal hereditary motor neuropathy type 7.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | High affinity choline transporter 1 |
|---|---|
| UniProt accession | Q9GZV3 |
| Gene | SLC5A7 |
| Organism | Homo sapiens |
| Length | 580 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Transporter (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (213)
Diseases linked to this target (Open Targets).
- Presynaptic congenital myasthenic syndromes · score 0.75
- Congenital myasthenic syndromes · score 0.67
- distal hereditary motor neuropathy type 7 · score 0.58
- hereditary motor and sensory neuropathy · score 0.37
- Charcot-Marie-Tooth disease type 2 · score 0.27
- genetic disorder · score 0.19
- cutaneous melanoma · score 0.18
- malate measurement · score 0.13
- squamous cell lung carcinoma · score 0.12
- distal hereditary motor neuropathy · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZV3-F1 | alphafold | PREDICTED | 84.35 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZV3.
Amino-acid sequence (580 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC5A7?
The strongest Open Targets associations for SLC5A7 are Presynaptic congenital myasthenic syndromes, Congenital myasthenic syndromes, distal hereditary motor neuropathy type 7, hereditary motor and sensory neuropathy and Charcot-Marie-Tooth disease type 2.
How long is the SLC5A7 protein?
The Homo sapiens SLC5A7 protein (UniProt Q9GZV3) is 580 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZV3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZV3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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