Eukaryotic translation initiation factor 5A-2 (EIF5A2)
Homo sapiens — UniProt Q9GZV4
Data last refreshed: (UniProt release unknown)
Key facts
Eukaryotic translation initiation factor 5A-2 (EIF5A2) is a protein from Homo sapiens identified by UniProt accession Q9GZV4, 153 residues long. MolForge cross-references it against 0 known binders and 142 disease associations.
- UniProt accession: Q9GZV4; gene symbol EIF5A2.
- Organism: Homo sapiens.
- Length: 153 amino acids.
- Top disease associations (Open Targets): lean body mass, type 2 diabetes mellitus and glucose measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Eukaryotic translation initiation factor 5A-2 |
|---|---|
| UniProt accession | Q9GZV4 |
| Gene | EIF5A2 |
| Organism | Homo sapiens |
| Length | 153 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (142)
Diseases linked to this target (Open Targets).
- lean body mass · score 0.29
- type 2 diabetes mellitus · score 0.27
- glucose measurement · score 0.24
- fat body mass · score 0.22
- urate measurement · score 0.22
- Varicose veins · score 0.22
- creatinine measurement · score 0.19
- HbA1c measurement · score 0.18
- IGF-1 measurement · score 0.16
- body mass index · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZV4-F1 | alphafold | PREDICTED | 87.73 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZV4.
Amino-acid sequence (153 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EIF5A2?
The strongest Open Targets associations for EIF5A2 are lean body mass, type 2 diabetes mellitus, glucose measurement, fat body mass and urate measurement.
How long is the EIF5A2 protein?
The Homo sapiens EIF5A2 protein (UniProt Q9GZV4) is 153 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZV4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZV4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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