WW domain-containing transcription regulator protein 1 (WWTR1)
Homo sapiens — UniProt Q9GZV5
Data last refreshed: (UniProt release unknown)
Key facts
WW domain-containing transcription regulator protein 1 (WWTR1) is a protein from Homo sapiens identified by UniProt accession Q9GZV5, 400 residues long. MolForge cross-references it against 0 known binders and 349 disease associations.
- UniProt accession: Q9GZV5; gene symbol WWTR1.
- Organism: Homo sapiens.
- Length: 400 amino acids.
- Top disease associations (Open Targets): refractive error measurement, body height and pancreatic ductal adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | WW domain-containing transcription regulator protein 1 |
|---|---|
| UniProt accession | Q9GZV5 |
| Gene | WWTR1 |
| Organism | Homo sapiens |
| Length | 400 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (349)
Diseases linked to this target (Open Targets).
- refractive error measurement · score 0.46
- body height · score 0.46
- pancreatic ductal adenocarcinoma · score 0.37
- neurodegenerative disease · score 0.37
- esophageal adenocarcinoma · score 0.37
- bile duct carcinoma · score 0.37
- kidney neoplasm · score 0.37
- lymphoid neoplasm · score 0.37
- prostate adenocarcinoma · score 0.37
- breast ductal adenocarcinoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZV5-F1 | alphafold | PREDICTED | 59.14 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZV5.
Amino-acid sequence (400 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with WWTR1?
The strongest Open Targets associations for WWTR1 are refractive error measurement, body height, pancreatic ductal adenocarcinoma, neurodegenerative disease and esophageal adenocarcinoma.
How long is the WWTR1 protein?
The Homo sapiens WWTR1 protein (UniProt Q9GZV5) is 400 amino acids long.
Browse: Targets: W · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZV5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZV5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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