Hyaluronan and proteoglycan link protein 2 (HAPLN2)
Homo sapiens — UniProt Q9GZV7
Data last refreshed: (UniProt release unknown)
Key facts
Hyaluronan and proteoglycan link protein 2 (HAPLN2) is a protein from Homo sapiens identified by UniProt accession Q9GZV7, 340 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.
- UniProt accession: Q9GZV7; gene symbol HAPLN2.
- Organism: Homo sapiens.
- Length: 340 amino acids.
- Top disease associations (Open Targets): blood protein measurement, white matter microstructure measurement and functional brain measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Hyaluronan and proteoglycan link protein 2 |
|---|---|
| UniProt accession | Q9GZV7 |
| Gene | HAPLN2 |
| Organism | Homo sapiens |
| Length | 340 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (16)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.18
- white matter microstructure measurement · score 0.12
- functional brain measurement · score 0.12
- Crohn's disease · score 0.02
- ependymoma · score 0.02
- nervous system disease · score 0.02
- schizophrenia · score 0.01
- Parkinson disease · score 0.01
- medulloblastoma · score 0.01
- glioblastoma multiforme · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZV7-F1 | alphafold | PREDICTED | 89.49 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZV7.
Amino-acid sequence (340 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HAPLN2?
The strongest Open Targets associations for HAPLN2 are blood protein measurement, white matter microstructure measurement, functional brain measurement, Crohn's disease and ependymoma.
How long is the HAPLN2 protein?
The Homo sapiens HAPLN2 protein (UniProt Q9GZV7) is 340 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZV7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZV7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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