Twisted gastrulation protein homolog 1 (TWSG1)
Homo sapiens — UniProt Q9GZX9
Data last refreshed: (UniProt release unknown)
Key facts
Twisted gastrulation protein homolog 1 (TWSG1) is a protein from Homo sapiens identified by UniProt accession Q9GZX9, 223 residues long. MolForge cross-references it against 0 known binders and 102 disease associations.
- UniProt accession: Q9GZX9; gene symbol TWSG1.
- Organism: Homo sapiens.
- Length: 223 amino acids.
- Top disease associations (Open Targets): metabolite measurement, gut microbiome measurement and papillary thyroid carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Twisted gastrulation protein homolog 1 |
|---|---|
| UniProt accession | Q9GZX9 |
| Gene | TWSG1 |
| Organism | Homo sapiens |
| Length | 223 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (102)
Diseases linked to this target (Open Targets).
- metabolite measurement · score 0.28
- gut microbiome measurement · score 0.08
- papillary thyroid carcinoma · score 0.08
- neoplasm · score 0.05
- platelet component distribution width · score 0.05
- otodental syndrome · score 0.05
- mean corpuscular volume · score 0.04
- mean corpuscular hemoglobin concentration · score 0.04
- Schimke immuno-osseous dysplasia · score 0.04
- cortical surface area measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZX9-F1 | alphafold | PREDICTED | 80.36 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZX9.
Amino-acid sequence (223 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TWSG1?
The strongest Open Targets associations for TWSG1 are metabolite measurement, gut microbiome measurement, papillary thyroid carcinoma, neoplasm and platelet component distribution width.
How long is the TWSG1 protein?
The Homo sapiens TWSG1 protein (UniProt Q9GZX9) is 223 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZX9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZX9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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