Nuclear RNA export factor 2 (NXF2)
Homo sapiens — UniProt Q9GZY0
Data last refreshed: (UniProt release unknown)
Key facts
Nuclear RNA export factor 2 (NXF2) is a protein from Homo sapiens identified by UniProt accession Q9GZY0, 626 residues long. MolForge cross-references it against 0 known binders and 113 disease associations.
- UniProt accession: Q9GZY0; gene symbol NXF2.
- Organism: Homo sapiens.
- Length: 626 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, azoospermia and partial chromosome Y deletion.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nuclear RNA export factor 2 |
|---|---|
| UniProt accession | Q9GZY0 |
| Gene | NXF2 |
| Organism | Homo sapiens |
| Length | 626 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (113)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- azoospermia · score 0.09
- partial chromosome Y deletion · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- spermatogenic failure 63 · score 0.08
- spermatogenic failure 25 · score 0.07
- spermatogenic failures 50 · score 0.07
- isochromosomy Yp · score 0.07
- spermatogenic failure 65 · score 0.07
- spermatogenic failure 56 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZY0-F1 | alphafold | PREDICTED | 76.67 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZY0.
Amino-acid sequence (626 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NXF2?
The strongest Open Targets associations for NXF2 are neurodegenerative disease, azoospermia, partial chromosome Y deletion, male infertility with teratozoospermia due to single gene mutation and spermatogenic failure 63.
How long is the NXF2 protein?
The Homo sapiens NXF2 protein (UniProt Q9GZY0) is 626 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZY0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZY0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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