Cytochrome c oxidase assembly factor 1 homolog (COA1)
Homo sapiens — UniProt Q9GZY4
Data last refreshed: (UniProt release unknown)
Key facts
Cytochrome c oxidase assembly factor 1 homolog (COA1) is a protein from Homo sapiens identified by UniProt accession Q9GZY4, 146 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.
- UniProt accession: Q9GZY4; gene symbol COA1.
- Organism: Homo sapiens.
- Length: 146 amino acids.
- Top disease associations (Open Targets): mean corpuscular volume, pulmonary non-tuberculous mycobacterial infection and cataract.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cytochrome c oxidase assembly factor 1 homolog |
|---|---|
| UniProt accession | Q9GZY4 |
| Gene | COA1 |
| Organism | Homo sapiens |
| Length | 146 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (25)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.33
- pulmonary non-tuberculous mycobacterial infection · score 0.25
- cataract · score 0.24
- brain measurement · score 0.22
- cortical surface area measurement · score 0.21
- urate measurement · score 0.19
- neurodegenerative disease · score 0.19
- brain volume measurement · score 0.18
- peak insulin response measurement · score 0.17
- mean corpuscular hemoglobin concentration · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZY4-F1 | alphafold | PREDICTED | 88.21 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZY4.
Amino-acid sequence (146 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with COA1?
The strongest Open Targets associations for COA1 are mean corpuscular volume, pulmonary non-tuberculous mycobacterial infection, cataract, brain measurement and cortical surface area measurement.
How long is the COA1 protein?
The Homo sapiens COA1 protein (UniProt Q9GZY4) is 146 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZY4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZY4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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