Linker for activation of T-cells family member 2 (LAT2)
Homo sapiens — UniProt Q9GZY6
Data last refreshed: (UniProt release unknown)
Key facts
Linker for activation of T-cells family member 2 (LAT2) is a protein from Homo sapiens identified by UniProt accession Q9GZY6, 243 residues long. MolForge cross-references it against 0 known binders and 124 disease associations.
- UniProt accession: Q9GZY6; gene symbol LAT2.
- Organism: Homo sapiens.
- Length: 243 amino acids.
- Top disease associations (Open Targets): glioblastoma multiforme, total blood protein measurement and acute myeloid leukemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Linker for activation of T-cells family member 2 |
|---|---|
| UniProt accession | Q9GZY6 |
| Gene | LAT2 |
| Organism | Homo sapiens |
| Length | 243 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (124)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.19
- total blood protein measurement · score 0.10
- acute myeloid leukemia · score 0.08
- neutrophil immunodeficiency syndrome · score 0.07
- autoimmune disease · score 0.07
- acute promyelocytic leukemia · score 0.07
- C1 inhibitor deficiency · score 0.06
- immunodeficiency 18 · score 0.06
- common variable immunodeficiency · score 0.06
- autoimmune lymphoproliferative syndrome type 2B · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZY6-F1 | alphafold | PREDICTED | 61.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZY6.
Amino-acid sequence (243 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LAT2?
The strongest Open Targets associations for LAT2 are glioblastoma multiforme, total blood protein measurement, acute myeloid leukemia, neutrophil immunodeficiency syndrome and autoimmune disease.
How long is the LAT2 protein?
The Homo sapiens LAT2 protein (UniProt Q9GZY6) is 243 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZY6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZY6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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