Mitochondrial fission factor (MFF)
Homo sapiens — UniProt Q9GZY8
Data last refreshed: (UniProt release unknown)
Key facts
Mitochondrial fission factor (MFF) is a protein from Homo sapiens identified by UniProt accession Q9GZY8, 342 residues long. MolForge cross-references it against 0 known binders and 138 disease associations.
- UniProt accession: Q9GZY8; gene symbol MFF.
- Organism: Homo sapiens.
- Length: 342 amino acids.
- Top disease associations (Open Targets): Lethal encephalopathy due to mitochondrial and peroxisomal fission defect, neurodegenerative disease and hematocrit.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mitochondrial fission factor |
|---|---|
| UniProt accession | Q9GZY8 |
| Gene | MFF |
| Organism | Homo sapiens |
| Length | 342 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (138)
Diseases linked to this target (Open Targets).
- Lethal encephalopathy due to mitochondrial and peroxisomal fission defect · score 0.76
- neurodegenerative disease · score 0.44
- hematocrit · score 0.36
- hemoglobin measurement · score 0.36
- central corneal thickness · score 0.28
- mitochondrial encephalomyopathy · score 0.26
- Global developmental delay · score 0.26
- red blood cell density measurement · score 0.25
- intraocular pressure measurement · score 0.23
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZY8-F1 | alphafold | PREDICTED | 63.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZY8.
Amino-acid sequence (342 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MFF?
The strongest Open Targets associations for MFF are Lethal encephalopathy due to mitochondrial and peroxisomal fission defect, neurodegenerative disease, hematocrit, hemoglobin measurement and central corneal thickness.
How long is the MFF protein?
The Homo sapiens MFF protein (UniProt Q9GZY8) is 342 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZY8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZY8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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