Homeobox protein Hox-D1 (HOXD1)
Homo sapiens — UniProt Q9GZZ0
Data last refreshed: (UniProt release unknown)
Key facts
Homeobox protein Hox-D1 (HOXD1) is a protein from Homo sapiens identified by UniProt accession Q9GZZ0, 328 residues long. MolForge cross-references it against 0 known binders and 97 disease associations.
- UniProt accession: Q9GZZ0; gene symbol HOXD1.
- Organism: Homo sapiens.
- Length: 328 amino acids.
- Top disease associations (Open Targets): systolic blood pressure, cystatin C measurement and serum urea measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Homeobox protein Hox-D1 |
|---|---|
| UniProt accession | Q9GZZ0 |
| Gene | HOXD1 |
| Organism | Homo sapiens |
| Length | 328 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (97)
Diseases linked to this target (Open Targets).
- systolic blood pressure · score 0.25
- cystatin C measurement · score 0.21
- serum urea measurement · score 0.20
- diet measurement · score 0.19
- head and neck squamous cell carcinoma · score 0.15
- gout · score 0.12
- myocardial infarction · score 0.11
- urate measurement · score 0.11
- hair shape measurement · score 0.11
- FEV/FVC ratio · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZZ0-F1 | alphafold | PREDICTED | 59.56 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZZ0.
Amino-acid sequence (328 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HOXD1?
The strongest Open Targets associations for HOXD1 are systolic blood pressure, cystatin C measurement, serum urea measurement, diet measurement and head and neck squamous cell carcinoma.
How long is the HOXD1 protein?
The Homo sapiens HOXD1 protein (UniProt Q9GZZ0) is 328 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZZ0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZZ0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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