Neuronal acetylcholine receptor subunit alpha-10 (CHRNA10)
Homo sapiens — UniProt Q9GZZ6
Data last refreshed: (UniProt release unknown)
Key facts
Neuronal acetylcholine receptor subunit alpha-10 (CHRNA10) is a protein from Homo sapiens identified by UniProt accession Q9GZZ6, 450 residues long. MolForge cross-references it against 3 known binders and 14 disease associations.
- UniProt accession: Q9GZZ6; gene symbol CHRNA10.
- Organism: Homo sapiens.
- Length: 450 amino acids.
- Top disease associations (Open Targets): Tinnitus, neurodegenerative disease and Alzheimer disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Neuronal acetylcholine receptor subunit alpha-10 |
|---|---|
| UniProt accession | Q9GZZ6 |
| Gene | CHRNA10 |
| Organism | Homo sapiens |
| Length | 450 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (14)
Diseases linked to this target (Open Targets).
- Tinnitus · score 0.40
- neurodegenerative disease · score 0.32
- Alzheimer disease · score 0.26
- DNA methylation · score 0.22
- visual perception measurement · score 0.19
- metabolite measurement · score 0.03
- blood protein measurement · score 0.02
- waist circumference · score 0.02
- experimental autoimmune encephalomyelitis · score 0.01
- neoplasm · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZZ6-F1 | alphafold | PREDICTED | 82.20 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZZ6.
Amino-acid sequence (450 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CHRNA10?
The strongest Open Targets associations for CHRNA10 are Tinnitus, neurodegenerative disease, Alzheimer disease, DNA methylation and visual perception measurement.
How long is the CHRNA10 protein?
The Homo sapiens CHRNA10 protein (UniProt Q9GZZ6) is 450 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZZ6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZZ6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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