GDNF family receptor alpha-4 (GFRA4)
Homo sapiens — UniProt Q9GZZ7
Data last refreshed: (UniProt release unknown)
Key facts
GDNF family receptor alpha-4 (GFRA4) is a protein from Homo sapiens identified by UniProt accession Q9GZZ7, 299 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.
- UniProt accession: Q9GZZ7; gene symbol GFRA4.
- Organism: Homo sapiens.
- Length: 299 amino acids.
- Top disease associations (Open Targets): glioblastoma multiforme, reticulocyte count and fetal akinesia deformation sequence 1.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | GDNF family receptor alpha-4 |
|---|---|
| UniProt accession | Q9GZZ7 |
| Gene | GFRA4 |
| Organism | Homo sapiens |
| Length | 299 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (39)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.29
- reticulocyte count · score 0.13
- fetal akinesia deformation sequence 1 · score 0.12
- fetal akinesia deformation sequence · score 0.12
- arthrogryposis multiplex congenita · score 0.12
- monocyte count · score 0.12
- reticulocyte measurement · score 0.08
- leukocyte count · score 0.07
- hyperthyroxinemia · score 0.06
- thyroid hormone metabolism, abnormal, 3 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZZ7-F1 | alphafold | PREDICTED | 68.56 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZZ7.
Amino-acid sequence (299 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GFRA4?
The strongest Open Targets associations for GFRA4 are glioblastoma multiforme, reticulocyte count, fetal akinesia deformation sequence 1, fetal akinesia deformation sequence and arthrogryposis multiplex congenita.
How long is the GFRA4 protein?
The Homo sapiens GFRA4 protein (UniProt Q9GZZ7) is 299 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZZ7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZZ7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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