Extracellular glycoprotein lacritin (LACRT)
Homo sapiens — UniProt Q9GZZ8
Data last refreshed: (UniProt release unknown)
Key facts
Extracellular glycoprotein lacritin (LACRT) is a protein from Homo sapiens identified by UniProt accession Q9GZZ8, 138 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.
- UniProt accession: Q9GZZ8; gene symbol LACRT.
- Organism: Homo sapiens.
- Length: 138 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, dry eye syndrome and lower respiratory tract disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Extracellular glycoprotein lacritin |
|---|---|
| UniProt accession | Q9GZZ8 |
| Gene | LACRT |
| Organism | Homo sapiens |
| Length | 138 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (30)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- dry eye syndrome · score 0.07
- lower respiratory tract disease · score 0.02
- psoriasis · score 0.02
- Sjogren syndrome · score 0.01
- breast cancer · score 0.01
- gonorrhea · score 0.01
- infect · score 0.01
- infection · score 0.01
- diabetes mellitus · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZZ8-F1 | alphafold | PREDICTED | 56.56 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZZ8.
Amino-acid sequence (138 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LACRT?
The strongest Open Targets associations for LACRT are neurodegenerative disease, dry eye syndrome, lower respiratory tract disease, psoriasis and Sjogren syndrome.
How long is the LACRT protein?
The Homo sapiens LACRT protein (UniProt Q9GZZ8) is 138 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZZ8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZZ8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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