Ubiquitin-like modifier-activating enzyme 5 (UBA5)
Homo sapiens — UniProt Q9GZZ9
Data last refreshed: (UniProt release unknown)
Key facts
Ubiquitin-like modifier-activating enzyme 5 (UBA5) is a protein from Homo sapiens identified by UniProt accession Q9GZZ9, 404 residues long. MolForge cross-references it against 0 known binders and 78 disease associations.
- UniProt accession: Q9GZZ9; gene symbol UBA5.
- Organism: Homo sapiens.
- Length: 404 amino acids.
- Top disease associations (Open Targets): developmental and epileptic encephalopathy, 44, spinocerebellar ataxia, autosomal recessive 24 and developmental and epileptic encephalopathy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ubiquitin-like modifier-activating enzyme 5 |
|---|---|
| UniProt accession | Q9GZZ9 |
| Gene | UBA5 |
| Organism | Homo sapiens |
| Length | 404 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (78)
Diseases linked to this target (Open Targets).
- developmental and epileptic encephalopathy, 44 · score 0.76
- spinocerebellar ataxia, autosomal recessive 24 · score 0.63
- developmental and epileptic encephalopathy · score 0.56
- neurodegenerative disease · score 0.53
- Childhood-onset autosomal recessive slowly progressive spinocerebellar ataxia · score 0.46
- genetic disorder · score 0.45
- Intellectual disability · score 0.37
- undetermined early-onset epileptic encephalopathy · score 0.37
- clear cell renal carcinoma · score 0.18
- otitis externa · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZZ9-F1 | alphafold | PREDICTED | 86.74 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZZ9.
Amino-acid sequence (404 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with UBA5?
The strongest Open Targets associations for UBA5 are developmental and epileptic encephalopathy, 44, spinocerebellar ataxia, autosomal recessive 24, developmental and epileptic encephalopathy, neurodegenerative disease and Childhood-onset autosomal recessive slowly progressive spinocerebellar ataxia.
How long is the UBA5 protein?
The Homo sapiens UBA5 protein (UniProt Q9GZZ9) is 404 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZZ9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZZ9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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