E3 ubiquitin-protein ligase makorin-2 (MKRN2)

About E3 ubiquitin-protein ligase makorin-2

E3 ubiquitin-protein ligase makorin-2 (MKRN2) is a protein from Homo sapiens identified by UniProt accession Q9H000, 416 residues long. MolForge cross-references it against 0 known binders and 199 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase makorin-2
UniProt accession	Q9H000
Gene	MKRN2
Organism	Homo sapiens
Length	416 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (199)

Diseases linked to this target (Open Targets).

Noonan syndrome · score 0.65
rasopathy · score 0.53
dilated cardiomyopathy · score 0.49
Noonan syndrome with multiple lentigines · score 0.47
hypertrophic cardiomyopathy 1 · score 0.34
Rare familial disorder with hypertrophic cardiomyopathy · score 0.34
Abnormality of the cardiovascular system · score 0.34
genetic disorder · score 0.30
Red cell distribution width · score 0.25
eosinophil count · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9H000-F1	alphafold	PREDICTED	71.00	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H000.

Amino-acid sequence (416 residues)

MSTKQITCRY FMHGVCREGS QCLFSHDLAN SKPSTICKYY QKGYCAYGTR CRYDHTRPSA AAGGAVGTMA HSVPSPAFHS PHPPSEVTAS IVKTNSHEPG KREKRTLVLR DRNLSGMAER KTQPSMVSNP GSCSDPQPSP EMKPHSYLDA IRSGLDDVEA SSSYSNEQQL CPYAAAGECR FGDACVYLHG EVCEICRLQV LHPFDPEQRK AHEKICMLTF EHEMEKAFAF QASQDKVCSI CMEVILEKAS ASERRFGILS NCNHTYCLSC IRQWRCAKQF ENPIIKSCPE CRVISEFVIP SVYWVEDQNK KNELIEAFKQ GMGKKACKYF EQGKGTCPFG SKCLYRHAYP DGRLAEPEKP RKQLSSQGTV RFFNSVRLWD FIENRESRHV PNNEDVDMTE LGDLFMHLSG VESSEP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards