Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP)
Homo sapiens — UniProt Q9H008
Data last refreshed: (UniProt release unknown)
Key facts
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) is a protein from Homo sapiens identified by UniProt accession Q9H008, 270 residues long. MolForge cross-references it against 0 known binders and 103 disease associations.
- UniProt accession: Q9H008; gene symbol LHPP.
- Organism: Homo sapiens.
- Length: 270 amino acids.
- Top disease associations (Open Targets): body height, B-cell acute lymphoblastic leukemia and lean body mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Phospholysine phosphohistidine inorganic pyrophosphate phosphatase |
|---|---|
| UniProt accession | Q9H008 |
| Gene | LHPP |
| Organism | Homo sapiens |
| Length | 270 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (103)
Diseases linked to this target (Open Targets).
- body height · score 0.44
- B-cell acute lymphoblastic leukemia · score 0.39
- lean body mass · score 0.33
- alcohol dependence · score 0.32
- risky sexual behaviour measurement · score 0.32
- behavioural disinhibition measurement · score 0.32
- fat body mass · score 0.31
- Testicular Germ Cell Tumor · score 0.29
- serum metabolite measurement · score 0.28
- open-angle glaucoma · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H008-F1 | alphafold | PREDICTED | 97.16 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H008.
Amino-acid sequence (270 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LHPP?
The strongest Open Targets associations for LHPP are body height, B-cell acute lymphoblastic leukemia, lean body mass, alcohol dependence and risky sexual behaviour measurement.
How long is the LHPP protein?
The Homo sapiens LHPP protein (UniProt Q9H008) is 270 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H008 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H008 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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