Transmembrane protein 126A (TMEM126A)
Homo sapiens — UniProt Q9H061
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 126A (TMEM126A) is a protein from Homo sapiens identified by UniProt accession Q9H061, 195 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.
- UniProt accession: Q9H061; gene symbol TMEM126A.
- Organism: Homo sapiens.
- Length: 195 amino acids.
- Top disease associations (Open Targets): autosomal recessive optic atrophy, OPA7 type, Leber hereditary optic neuropathy and Optic atrophy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 126A |
|---|---|
| UniProt accession | Q9H061 |
| Gene | TMEM126A |
| Organism | Homo sapiens |
| Length | 195 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (48)
Diseases linked to this target (Open Targets).
- autosomal recessive optic atrophy, OPA7 type · score 0.56
- Leber hereditary optic neuropathy · score 0.41
- Optic atrophy · score 0.37
- optic atrophy · score 0.37
- body fat percentage · score 0.13
- Okt4 epitope deficiency · score 0.06
- lean body mass · score 0.05
- fat body mass · score 0.05
- combined immunodeficiency with skin granulomas · score 0.05
- 22q11.2 deletion syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H061-F1 | alphafold | PREDICTED | 89.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H061.
Amino-acid sequence (195 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM126A?
The strongest Open Targets associations for TMEM126A are autosomal recessive optic atrophy, OPA7 type, Leber hereditary optic neuropathy, Optic atrophy, optic atrophy and body fat percentage.
How long is the TMEM126A protein?
The Homo sapiens TMEM126A protein (UniProt Q9H061) is 195 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H061 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H061 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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