Repressor of RNA polymerase III transcription MAF1 homolog (MAF1)
Homo sapiens — UniProt Q9H063
Data last refreshed: (UniProt release unknown)
Key facts
Repressor of RNA polymerase III transcription MAF1 homolog (MAF1) is a protein from Homo sapiens identified by UniProt accession Q9H063, 256 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.
- UniProt accession: Q9H063; gene symbol MAF1.
- Organism: Homo sapiens.
- Length: 256 amino acids.
- Top disease associations (Open Targets): mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin and mean corpuscular volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Repressor of RNA polymerase III transcription MAF1 homolog |
|---|---|
| UniProt accession | Q9H063 |
| Gene | MAF1 |
| Organism | Homo sapiens |
| Length | 256 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (61)
Diseases linked to this target (Open Targets).
- mean corpuscular hemoglobin concentration · score 0.17
- mean corpuscular hemoglobin · score 0.15
- mean corpuscular volume · score 0.15
- blood metabolite measurement · score 0.12
- eosinophil count · score 0.12
- neoplasm · score 0.09
- mean reticulocyte volume · score 0.09
- BMI-adjusted waist circumference · score 0.08
- hepatocellular carcinoma · score 0.08
- cardiac hypertrophy · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H063-F1 | alphafold | PREDICTED | 76.76 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H063.
Amino-acid sequence (256 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MAF1?
The strongest Open Targets associations for MAF1 are mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, mean corpuscular volume, blood metabolite measurement and eosinophil count.
How long is the MAF1 protein?
The Homo sapiens MAF1 protein (UniProt Q9H063) is 256 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H063 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H063 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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