Mitochondrial disaggregase (CLPB)
Homo sapiens — UniProt Q9H078
Data last refreshed: (UniProt release unknown)
Key facts
Mitochondrial disaggregase (CLPB) is a protein from Homo sapiens identified by UniProt accession Q9H078, 707 residues long. MolForge cross-references it against 0 known binders and 94 disease associations.
- UniProt accession: Q9H078; gene symbol CLPB.
- Organism: Homo sapiens.
- Length: 707 amino acids.
- Top disease associations (Open Targets): 3-methylglutaconic aciduria, type VIIB, neutropenia, severe congenital, 9, autosomal dominant and 3-methylglutaconic aciduria with cataracts, neurologic involvement, and neutropenia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mitochondrial disaggregase |
|---|---|
| UniProt accession | Q9H078 |
| Gene | CLPB |
| Organism | Homo sapiens |
| Length | 707 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (94)
Diseases linked to this target (Open Targets).
- 3-methylglutaconic aciduria, type VIIB · score 0.85
- neutropenia, severe congenital, 9, autosomal dominant · score 0.76
- 3-methylglutaconic aciduria with cataracts, neurologic involvement, and neutropenia · score 0.57
- genetic disorder · score 0.49
- neutropenia · score 0.42
- Premature ovarian insufficiency · score 0.42
- autosomal dominant severe congenital neutropenia · score 0.37
- 3-methylglutaconic aciduria · score 0.34
- 3-Methylglutaric aciduria · score 0.34
- Myeloid maturation arrest · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H078-F1 | alphafold | PREDICTED | 71.76 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H078.
Amino-acid sequence (707 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CLPB?
The strongest Open Targets associations for CLPB are 3-methylglutaconic aciduria, type VIIB, neutropenia, severe congenital, 9, autosomal dominant, 3-methylglutaconic aciduria with cataracts, neurologic involvement, and neutropenia, genetic disorder and neutropenia.
How long is the CLPB protein?
The Homo sapiens CLPB protein (UniProt Q9H078) is 707 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H078 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H078 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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