Protein MIS12 homolog (MIS12)
Homo sapiens — UniProt Q9H081
Data last refreshed: (UniProt release unknown)
Key facts
Protein MIS12 homolog (MIS12) is a protein from Homo sapiens identified by UniProt accession Q9H081, 205 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.
- UniProt accession: Q9H081; gene symbol MIS12.
- Organism: Homo sapiens.
- Length: 205 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, hematocrit and platelet component distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein MIS12 homolog |
|---|---|
| UniProt accession | Q9H081 |
| Gene | MIS12 |
| Organism | Homo sapiens |
| Length | 205 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (16)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.39
- hematocrit · score 0.04
- platelet component distribution width · score 0.03
- diastolic blood pressure · score 0.03
- smoking status measurement · score 0.03
- cancer · score 0.02
- muscle atrophy · score 0.01
- Ataxia-telangiectasia · score 0.01
- cervical squamous intraepithelial neoplasia · score 0.01
- pachyonychia congenita · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H081-F1 | alphafold | PREDICTED | 87.79 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H081.
Amino-acid sequence (205 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MIS12?
The strongest Open Targets associations for MIS12 are neurodegenerative disease, hematocrit, platelet component distribution width, diastolic blood pressure and smoking status measurement.
How long is the MIS12 protein?
The Homo sapiens MIS12 protein (UniProt Q9H081) is 205 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H081 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H081 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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