Large subunit GTPase 1 homolog (LSG1)
Homo sapiens — UniProt Q9H089
Data last refreshed: (UniProt release unknown)
Key facts
Large subunit GTPase 1 homolog (LSG1) is a protein from Homo sapiens identified by UniProt accession Q9H089, 658 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.
- UniProt accession: Q9H089; gene symbol LSG1.
- Organism: Homo sapiens.
- Length: 658 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, reticulocyte count and hemoglobin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Large subunit GTPase 1 homolog |
|---|---|
| UniProt accession | Q9H089 |
| Gene | LSG1 |
| Organism | Homo sapiens |
| Length | 658 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (29)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- reticulocyte count · score 0.26
- hemoglobin measurement · score 0.26
- hematocrit · score 0.26
- erythrocyte count · score 0.25
- eosinophil count · score 0.24
- red blood cell density measurement · score 0.20
- cortical thickness · score 0.20
- reticulocyte measurement · score 0.20
- mean corpuscular hemoglobin concentration · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H089-F1 | alphafold | PREDICTED | 69.43 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H089.
Amino-acid sequence (658 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LSG1?
The strongest Open Targets associations for LSG1 are neurodegenerative disease, reticulocyte count, hemoglobin measurement, hematocrit and erythrocyte count.
How long is the LSG1 protein?
The Homo sapiens LSG1 protein (UniProt Q9H089) is 658 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H089 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H089 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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