NUAK family SNF1-like kinase 2 (NUAK2)
Homo sapiens — UniProt Q9H093
Data last refreshed: (UniProt release unknown)
Key facts
NUAK family SNF1-like kinase 2 (NUAK2) is a protein from Homo sapiens identified by UniProt accession Q9H093, 628 residues long. MolForge cross-references it against 15 known binders and 128 disease associations.
- UniProt accession: Q9H093; gene symbol NUAK2.
- Organism: Homo sapiens.
- Length: 628 amino acids.
- Approved drugs acting on it (DrugCentral): Trilaciclib.
- Top disease associations (Open Targets): anencephaly 2, neurodegenerative disease and neuroinflammatory disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | NUAK family SNF1-like kinase 2 |
|---|---|
| UniProt accession | Q9H093 |
| Gene | NUAK2 |
| Organism | Homo sapiens |
| Length | 628 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (128)
Diseases linked to this target (Open Targets).
- anencephaly 2 · score 0.46
- neurodegenerative disease · score 0.41
- neuroinflammatory disorder · score 0.36
- Alzheimer disease · score 0.34
- lysosomal storage disease · score 0.34
- multiple sclerosis · score 0.34
- Parkinson disease · score 0.34
- mean platelet volume · score 0.21
- anencephaly · score 0.18
- platelet count · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H093-F1 | alphafold | PREDICTED | 62.28 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H093.
Amino-acid sequence (628 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target NUAK2?
DrugCentral lists 1 approved drug whose mechanism of action is NUAK2: Trilaciclib.
Which diseases are associated with NUAK2?
The strongest Open Targets associations for NUAK2 are anencephaly 2, neurodegenerative disease, neuroinflammatory disorder, Alzheimer disease and lysosomal storage disease.
How long is the NUAK2 protein?
The Homo sapiens NUAK2 protein (UniProt Q9H093) is 628 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H093 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H093 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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