COMM domain-containing protein 4 (COMMD4)
Homo sapiens — UniProt Q9H0A8
Data last refreshed: (UniProt release unknown)
Key facts
COMM domain-containing protein 4 (COMMD4) is a protein from Homo sapiens identified by UniProt accession Q9H0A8, 199 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.
- UniProt accession: Q9H0A8; gene symbol COMMD4.
- Organism: Homo sapiens.
- Length: 199 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, urate measurement and creatinine measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | COMM domain-containing protein 4 |
|---|---|
| UniProt accession | Q9H0A8 |
| Gene | COMMD4 |
| Organism | Homo sapiens |
| Length | 199 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (33)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.41
- urate measurement · score 0.12
- creatinine measurement · score 0.10
- glomerular filtration rate · score 0.10
- non-small cell lung carcinoma · score 0.09
- urinary albumin to creatinine ratio · score 0.09
- cystatin C measurement · score 0.09
- uric acid measurement · score 0.08
- type 2 diabetes mellitus · score 0.07
- body height · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0A8-F1 | alphafold | PREDICTED | 80.75 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0A8.
Amino-acid sequence (199 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with COMMD4?
The strongest Open Targets associations for COMMD4 are neurodegenerative disease, urate measurement, creatinine measurement, glomerular filtration rate and non-small cell lung carcinoma.
How long is the COMMD4 protein?
The Homo sapiens COMMD4 protein (UniProt Q9H0A8) is 199 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0A8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0A8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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