Kinesin light chain 2 (KLC2)
Homo sapiens — UniProt Q9H0B6
Data last refreshed: (UniProt release unknown)
Key facts
Kinesin light chain 2 (KLC2) is a protein from Homo sapiens identified by UniProt accession Q9H0B6, 622 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.
- UniProt accession: Q9H0B6; gene symbol KLC2.
- Organism: Homo sapiens.
- Length: 622 amino acids.
- Top disease associations (Open Targets): Spastic paraplegia-optic atrophy-neuropathy syndrome, spastic paraplegia, optic atropy, and neuropathy and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Kinesin light chain 2 |
|---|---|
| UniProt accession | Q9H0B6 |
| Gene | KLC2 |
| Organism | Homo sapiens |
| Length | 622 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (39)
Diseases linked to this target (Open Targets).
- Spastic paraplegia-optic atrophy-neuropathy syndrome · score 0.50
- spastic paraplegia, optic atropy, and neuropathy · score 0.46
- neurodegenerative disease · score 0.33
- Immature Reticulocyte Fraction Measurement · score 0.23
- breast adenocarcinoma · score 0.18
- mean reticulocyte volume · score 0.16
- glioblastoma multiforme · score 0.15
- bipolar disorder · score 0.12
- mean platelet volume · score 0.10
- Anal fissure · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0B6-F1 | alphafold | PREDICTED | 71.85 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0B6.
Amino-acid sequence (622 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KLC2?
The strongest Open Targets associations for KLC2 are Spastic paraplegia-optic atrophy-neuropathy syndrome, spastic paraplegia, optic atropy, and neuropathy, neurodegenerative disease, Immature Reticulocyte Fraction Measurement and breast adenocarcinoma.
How long is the KLC2 protein?
The Homo sapiens KLC2 protein (UniProt Q9H0B6) is 622 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0B6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0B6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.