Transmembrane protein 117 (TMEM117)
Homo sapiens — UniProt Q9H0C3
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 117 (TMEM117) is a protein from Homo sapiens identified by UniProt accession Q9H0C3, 514 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.
- UniProt accession: Q9H0C3; gene symbol TMEM117.
- Organism: Homo sapiens.
- Length: 514 amino acids.
- Top disease associations (Open Targets): cardiac hypertrophy, Hypoglycemia and non-small cell lung carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 117 |
|---|---|
| UniProt accession | Q9H0C3 |
| Gene | TMEM117 |
| Organism | Homo sapiens |
| Length | 514 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (16)
Diseases linked to this target (Open Targets).
- cardiac hypertrophy · score 0.07
- Hypoglycemia · score 0.02
- non-small cell lung carcinoma · score 0.02
- cancer · score 0.01
- Kidney Oncocytoma · score 0.01
- gonorrhea · score 0.01
- cervical squamous cell carcinoma · score 0.00
- rubella · score 0.00
- inflammatory bowel disease · score 0.00
- chromophobe renal cell carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0C3-F1 | alphafold | PREDICTED | 74.72 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0C3.
Amino-acid sequence (514 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM117?
The strongest Open Targets associations for TMEM117 are cardiac hypertrophy, Hypoglycemia, non-small cell lung carcinoma, cancer and Kidney Oncocytoma.
How long is the TMEM117 protein?
The Homo sapiens TMEM117 protein (UniProt Q9H0C3) is 514 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0C3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0C3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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