Integrin-linked kinase-associated serine/threonine phosphatase 2C (ILKAP)
Homo sapiens — UniProt Q9H0C8
Data last refreshed: (UniProt release unknown)
Key facts
Integrin-linked kinase-associated serine/threonine phosphatase 2C (ILKAP) is a protein from Homo sapiens identified by UniProt accession Q9H0C8, 392 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.
- UniProt accession: Q9H0C8; gene symbol ILKAP.
- Organism: Homo sapiens.
- Length: 392 amino acids.
- Top disease associations (Open Targets): mean corpuscular hemoglobin concentration, Red cell distribution width and mean corpuscular volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Integrin-linked kinase-associated serine/threonine phosphatase 2C |
|---|---|
| UniProt accession | Q9H0C8 |
| Gene | ILKAP |
| Organism | Homo sapiens |
| Length | 392 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (42)
Diseases linked to this target (Open Targets).
- mean corpuscular hemoglobin concentration · score 0.38
- Red cell distribution width · score 0.32
- mean corpuscular volume · score 0.30
- mean corpuscular hemoglobin · score 0.26
- hemoglobin A1 measurement · score 0.26
- phospholipid measurement · score 0.25
- neurodegenerative disease · score 0.24
- hemoglobin measurement · score 0.23
- transferrin saturation measurement · score 0.16
- serum iron measurement · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0C8-F1 | alphafold | PREDICTED | 81.11 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0C8.
Amino-acid sequence (392 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ILKAP?
The strongest Open Targets associations for ILKAP are mean corpuscular hemoglobin concentration, Red cell distribution width, mean corpuscular volume, mean corpuscular hemoglobin and hemoglobin A1 measurement.
How long is the ILKAP protein?
The Homo sapiens ILKAP protein (UniProt Q9H0C8) is 392 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0C8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0C8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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