5'-3' exoribonuclease 2 (XRN2)
Homo sapiens — UniProt Q9H0D6
Data last refreshed: (UniProt release unknown)
Key facts
5'-3' exoribonuclease 2 (XRN2) is a protein from Homo sapiens identified by UniProt accession Q9H0D6, 950 residues long. MolForge cross-references it against 0 known binders and 72 disease associations.
- UniProt accession: Q9H0D6; gene symbol XRN2.
- Organism: Homo sapiens.
- Length: 950 amino acids.
- Top disease associations (Open Targets): Red cell distribution width, mean corpuscular hemoglobin and mean corpuscular volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 5'-3' exoribonuclease 2 |
|---|---|
| UniProt accession | Q9H0D6 |
| Gene | XRN2 |
| Organism | Homo sapiens |
| Length | 950 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (72)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.39
- mean corpuscular hemoglobin · score 0.39
- mean corpuscular volume · score 0.38
- mean corpuscular hemoglobin concentration · score 0.33
- neurodegenerative disease · score 0.33
- erythrocyte count · score 0.32
- autism spectrum disorder · score 0.30
- red blood cell density measurement · score 0.26
- head and neck squamous cell carcinoma · score 0.25
- lung adenocarcinoma · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0D6-F1 | alphafold | PREDICTED | 77.59 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0D6.
Amino-acid sequence (950 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with XRN2?
The strongest Open Targets associations for XRN2 are Red cell distribution width, mean corpuscular hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin concentration and neurodegenerative disease.
How long is the XRN2 protein?
The Homo sapiens XRN2 protein (UniProt Q9H0D6) is 950 amino acids long.
Browse: Targets: X · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0D6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0D6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.