Toll-interacting protein (TOLLIP)
Homo sapiens — UniProt Q9H0E2
Data last refreshed: (UniProt release unknown)
Key facts
Toll-interacting protein (TOLLIP) is a protein from Homo sapiens identified by UniProt accession Q9H0E2, 274 residues long. MolForge cross-references it against 0 known binders and 145 disease associations.
- UniProt accession: Q9H0E2; gene symbol TOLLIP.
- Organism: Homo sapiens.
- Length: 274 amino acids.
- Top disease associations (Open Targets): interstitial lung disease, idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Toll-interacting protein |
|---|---|
| UniProt accession | Q9H0E2 |
| Gene | TOLLIP |
| Organism | Homo sapiens |
| Length | 274 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (145)
Diseases linked to this target (Open Targets).
- interstitial lung disease · score 0.36
- idiopathic pulmonary fibrosis · score 0.24
- chronic obstructive pulmonary disease · score 0.14
- acute lymphoblastic leukemia · score 0.13
- combined pulmonary fibrosis-emphysema syndrome · score 0.11
- breast adenocarcinoma · score 0.10
- hepatocellular carcinoma · score 0.08
- colitis · score 0.08
- adenoma · score 0.08
- Sepsis · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0E2-F1 | alphafold | PREDICTED | 80.19 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0E2.
Amino-acid sequence (274 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TOLLIP?
The strongest Open Targets associations for TOLLIP are interstitial lung disease, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, acute lymphoblastic leukemia and combined pulmonary fibrosis-emphysema syndrome.
How long is the TOLLIP protein?
The Homo sapiens TOLLIP protein (UniProt Q9H0E2) is 274 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0E2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0E2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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