Histone deacetylase complex subunit SAP130 (SAP130)
Homo sapiens — UniProt Q9H0E3
Data last refreshed: (UniProt release unknown)
Key facts
Histone deacetylase complex subunit SAP130 (SAP130) is a protein from Homo sapiens identified by UniProt accession Q9H0E3, 1048 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.
- UniProt accession: Q9H0E3; gene symbol SAP130.
- Organism: Homo sapiens.
- Length: 1048 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, appendicular lean mass and platelet count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Histone deacetylase complex subunit SAP130 |
|---|---|
| UniProt accession | Q9H0E3 |
| Gene | SAP130 |
| Organism | Homo sapiens |
| Length | 1048 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (40)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- appendicular lean mass · score 0.26
- platelet count · score 0.22
- breast adenocarcinoma · score 0.22
- acute myeloid leukemia · score 0.22
- endometrial cancer · score 0.11
- Agents acting on the renin-angiotensin system use measurement · score 0.11
- Aortic Coarctation · score 0.06
- familial thoracic aortic aneurysm and aortic dissection · score 0.06
- hypoplastic left heart syndrome 1 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0E3-F1 | alphafold | PREDICTED | 44.47 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0E3.
Amino-acid sequence (1048 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SAP130?
The strongest Open Targets associations for SAP130 are neurodegenerative disease, appendicular lean mass, platelet count, breast adenocarcinoma and acute myeloid leukemia.
How long is the SAP130 protein?
The Homo sapiens SAP130 protein (UniProt Q9H0E3) is 1048 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0E3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0E3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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