Bromodomain-containing protein 8 (BRD8)
Homo sapiens — UniProt Q9H0E9
Data last refreshed: (UniProt release unknown)
Key facts
Bromodomain-containing protein 8 (BRD8) is a protein from Homo sapiens identified by UniProt accession Q9H0E9, 1235 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.
- UniProt accession: Q9H0E9; gene symbol BRD8.
- Organism: Homo sapiens.
- Length: 1235 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, lysosomal storage disease and multiple sclerosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Bromodomain-containing protein 8 |
|---|---|
| UniProt accession | Q9H0E9 |
| Gene | BRD8 |
| Organism | Homo sapiens |
| Length | 1235 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (52)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.55
- lysosomal storage disease · score 0.37
- multiple sclerosis · score 0.37
- Alzheimer disease · score 0.37
- Parkinson disease · score 0.37
- breast adenocarcinoma · score 0.22
- mathematical ability · score 0.11
- self reported educational attainment · score 0.11
- resting heart rate · score 0.10
- seasonal allergic rhinitis · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0E9-F1 | alphafold | PREDICTED | 52.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0E9.
Amino-acid sequence (1235 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BRD8?
The strongest Open Targets associations for BRD8 are neurodegenerative disease, lysosomal storage disease, multiple sclerosis, Alzheimer disease and Parkinson disease.
How long is the BRD8 protein?
The Homo sapiens BRD8 protein (UniProt Q9H0E9) is 1235 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0E9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0E9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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