E3 ubiquitin-protein ligase RNF38 (RNF38)
Homo sapiens — UniProt Q9H0F5
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase RNF38 (RNF38) is a protein from Homo sapiens identified by UniProt accession Q9H0F5, 515 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.
- UniProt accession: Q9H0F5; gene symbol RNF38.
- Organism: Homo sapiens.
- Length: 515 amino acids.
- Top disease associations (Open Targets): drug use measurement, hepatocellular carcinoma and non-small cell lung carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF38 |
|---|---|
| UniProt accession | Q9H0F5 |
| Gene | RNF38 |
| Organism | Homo sapiens |
| Length | 515 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (50)
Diseases linked to this target (Open Targets).
- drug use measurement · score 0.20
- hepatocellular carcinoma · score 0.10
- non-small cell lung carcinoma · score 0.08
- age-related macular degeneration · score 0.08
- X-linked retinal dysplasia · score 0.08
- Familial exudative vitreoretinopathy · score 0.07
- severe early-childhood-onset retinal dystrophy · score 0.06
- age related macular degeneration 11 · score 0.05
- age related macular degeneration 7 · score 0.05
- age related macular degeneration 4 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0F5-F1 | alphafold | PREDICTED | 52.52 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0F5.
Amino-acid sequence (515 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNF38?
The strongest Open Targets associations for RNF38 are drug use measurement, hepatocellular carcinoma, non-small cell lung carcinoma, age-related macular degeneration and X-linked retinal dysplasia.
How long is the RNF38 protein?
The Homo sapiens RNF38 protein (UniProt Q9H0F5) is 515 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0F5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0F5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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