Sharpin (SHARPIN)
Homo sapiens — UniProt Q9H0F6
Data last refreshed: (UniProt release unknown)
Key facts
Sharpin (SHARPIN) is a protein from Homo sapiens identified by UniProt accession Q9H0F6, 387 residues long. MolForge cross-references it against 0 known binders and 323 disease associations.
- UniProt accession: Q9H0F6; gene symbol SHARPIN.
- Organism: Homo sapiens.
- Length: 387 amino acids.
- Top disease associations (Open Targets): neuroinflammatory disorder, creatinine measurement and eosinophil count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sharpin |
|---|---|
| UniProt accession | Q9H0F6 |
| Gene | SHARPIN |
| Organism | Homo sapiens |
| Length | 387 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (323)
Diseases linked to this target (Open Targets).
- neuroinflammatory disorder · score 0.37
- creatinine measurement · score 0.15
- eosinophil count · score 0.14
- asthma · score 0.14
- mean corpuscular hemoglobin concentration · score 0.14
- eosinophil percentage of leukocytes · score 0.13
- mean corpuscular volume · score 0.12
- glomerular filtration rate · score 0.12
- mean corpuscular hemoglobin · score 0.11
- blood metabolite measurement · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0F6-F1 | alphafold | PREDICTED | 74.25 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0F6.
Amino-acid sequence (387 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SHARPIN?
The strongest Open Targets associations for SHARPIN are neuroinflammatory disorder, creatinine measurement, eosinophil count, asthma and mean corpuscular hemoglobin concentration.
How long is the SHARPIN protein?
The Homo sapiens SHARPIN protein (UniProt Q9H0F6) is 387 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0F6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0F6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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