ADP-ribosylation factor-like protein 6 (ARL6)
Homo sapiens — UniProt Q9H0F7
Data last refreshed: (UniProt release unknown)
Key facts
ADP-ribosylation factor-like protein 6 (ARL6) is a protein from Homo sapiens identified by UniProt accession Q9H0F7, 186 residues long. MolForge cross-references it against 0 known binders and 107 disease associations.
- UniProt accession: Q9H0F7; gene symbol ARL6.
- Organism: Homo sapiens.
- Length: 186 amino acids.
- Top disease associations (Open Targets): Bardet-Biedl syndrome, retinitis pigmentosa and Bardet-Biedl syndrome 1.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ADP-ribosylation factor-like protein 6 |
|---|---|
| UniProt accession | Q9H0F7 |
| Gene | ARL6 |
| Organism | Homo sapiens |
| Length | 186 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (107)
Diseases linked to this target (Open Targets).
- Bardet-Biedl syndrome · score 0.75
- retinitis pigmentosa · score 0.71
- Bardet-Biedl syndrome 1 · score 0.62
- polydactyly · score 0.46
- Polydactyly · score 0.46
- Retinal dystrophy · score 0.45
- autosomal recessive retinitis pigmentosa · score 0.42
- Posterior column ataxia - retinitis pigmentosa · score 0.40
- Obesity · score 0.37
- obesity · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0F7-F1 | alphafold | PREDICTED | 94.71 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0F7.
Amino-acid sequence (186 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARL6?
The strongest Open Targets associations for ARL6 are Bardet-Biedl syndrome, retinitis pigmentosa, Bardet-Biedl syndrome 1, polydactyly and Polydactyly.
How long is the ARL6 protein?
The Homo sapiens ARL6 protein (UniProt Q9H0F7) is 186 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0F7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0F7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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