Nuclear speckle splicing regulatory protein 1 (NSRP1)
Homo sapiens — UniProt Q9H0G5
Data last refreshed: (UniProt release unknown)
Key facts
Nuclear speckle splicing regulatory protein 1 (NSRP1) is a protein from Homo sapiens identified by UniProt accession Q9H0G5, 558 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.
- UniProt accession: Q9H0G5; gene symbol NSRP1.
- Organism: Homo sapiens.
- Length: 558 amino acids.
- Top disease associations (Open Targets): Microcephaly, Severe global developmental delay and Seizure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nuclear speckle splicing regulatory protein 1 |
|---|---|
| UniProt accession | Q9H0G5 |
| Gene | NSRP1 |
| Organism | Homo sapiens |
| Length | 558 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (62)
Diseases linked to this target (Open Targets).
- Microcephaly · score 0.45
- Severe global developmental delay · score 0.45
- Seizure · score 0.45
- Spasticity · score 0.45
- mean corpuscular hemoglobin concentration · score 0.31
- total blood protein measurement · score 0.30
- QRS complex · score 0.27
- QRS amplitude · score 0.27
- body height · score 0.22
- brain volume measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0G5-F1 | alphafold | PREDICTED | 62.77 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0G5.
Amino-acid sequence (558 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NSRP1?
The strongest Open Targets associations for NSRP1 are Microcephaly, Severe global developmental delay, Seizure, Spasticity and mean corpuscular hemoglobin concentration.
How long is the NSRP1 protein?
The Homo sapiens NSRP1 protein (UniProt Q9H0G5) is 558 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0G5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0G5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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