Integrator complex subunit 2 (INTS2)
Homo sapiens — UniProt Q9H0H0
Data last refreshed: (UniProt release unknown)
Key facts
Integrator complex subunit 2 (INTS2) is a protein from Homo sapiens identified by UniProt accession Q9H0H0, 1196 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.
- UniProt accession: Q9H0H0; gene symbol INTS2.
- Organism: Homo sapiens.
- Length: 1196 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, self reported educational attainment and Parkinson disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Integrator complex subunit 2 |
|---|---|
| UniProt accession | Q9H0H0 |
| Gene | INTS2 |
| Organism | Homo sapiens |
| Length | 1196 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (25)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.35
- self reported educational attainment · score 0.28
- Parkinson disease · score 0.23
- mean corpuscular volume · score 0.22
- erythrocyte count · score 0.21
- body height · score 0.14
- mathematical ability · score 0.14
- exstrophy-epispadias complex · score 0.12
- coffee consumption measurement · score 0.11
- coffee consumption · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0H0-F1 | alphafold | PREDICTED | 78.59 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0H0.
Amino-acid sequence (1196 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with INTS2?
The strongest Open Targets associations for INTS2 are neurodegenerative disease, self reported educational attainment, Parkinson disease, mean corpuscular volume and erythrocyte count.
How long is the INTS2 protein?
The Homo sapiens INTS2 protein (UniProt Q9H0H0) is 1196 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0H0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0H0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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