Kelch-like protein 25 (KLHL25)
Homo sapiens — UniProt Q9H0H3
Data last refreshed: (UniProt release unknown)
Key facts
Kelch-like protein 25 (KLHL25) is a protein from Homo sapiens identified by UniProt accession Q9H0H3, 589 residues long. MolForge cross-references it against 0 known binders and 108 disease associations.
- UniProt accession: Q9H0H3; gene symbol KLHL25.
- Organism: Homo sapiens.
- Length: 589 amino acids.
- Top disease associations (Open Targets): lean body mass, appendicular lean mass and birth weight.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Kelch-like protein 25 |
|---|---|
| UniProt accession | Q9H0H3 |
| Gene | KLHL25 |
| Organism | Homo sapiens |
| Length | 589 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (108)
Diseases linked to this target (Open Targets).
- lean body mass · score 0.51
- appendicular lean mass · score 0.47
- birth weight · score 0.42
- fat body mass · score 0.41
- eosinophil percentage of leukocytes · score 0.39
- red blood cell density measurement · score 0.39
- aspartate aminotransferase measurement · score 0.37
- mean corpuscular volume · score 0.35
- eosinophil count · score 0.35
- parental genotype effect measurement · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0H3-F1 | alphafold | PREDICTED | 88.62 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0H3.
Amino-acid sequence (589 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KLHL25?
The strongest Open Targets associations for KLHL25 are lean body mass, appendicular lean mass, birth weight, fat body mass and eosinophil percentage of leukocytes.
How long is the KLHL25 protein?
The Homo sapiens KLHL25 protein (UniProt Q9H0H3) is 589 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0H3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0H3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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